Dermatology · Dermatology / Severe cutaneous adverse reactions
Toxic epidermal necrolysis
also: Lyell syndrome; TEN
Life-threatening skin detachment of over 30% body surface area.
- Specialty
- Dermatology
- Subspecialty
- Dermatology / Severe cutaneous adverse reactions
- Sex & age distribution
- Male: affected; Female: affected, slight female predominance; Children: yes, rare
- Gene(s) involved
- CYP2C9, HLA-A*31:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01
- Alternative names & eponyms
- Lyell syndrome; TEN
Etiology & mechanism
Drug-induced cytotoxic T-cell and NK-cell mediated keratinocyte death.
Gene(s) involved (5)
Symptoms & signs (7)
In plain terms, someone with Toxic epidermal necrolysis may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
4 shared
Stevens–Johnson syndrome
fever, mucosal erosions, painful skin, skin detachment
2 shared
Fournier gangrene syndrome
fever, sepsis
1 shared
Acquired immunodeficiency syndrome
fever
1 shared
Acute chest syndrome
fever
1 shared
Antisynthetase syndrome
fever
1 shared
Behçet-like haploinsufficiency of A20 syndrome
fever
1 shared
Boerhaave syndrome
fever
1 shared
Castleman syndrome
fever
1 shared
Congenital chloride diarrhea syndrome
dehydration
1 shared
Cryopyrin-associated periodic syndrome
fever
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