Dermatology · Dermatology / Severe cutaneous adverse reactions
Stevens–Johnson syndrome
also: SJS; SJS/TEN spectrum
Acute mucocutaneous reaction with detachment of under 10% body surface area.
- Specialty
- Dermatology
- Subspecialty
- Dermatology / Severe cutaneous adverse reactions
- Sex & age distribution
- Male: affected; Female: affected, slight female predominance; Children: yes, often drug or Mycoplasma related
- Gene(s) involved
- CYP2C9, HLA-A*31:01, HLA-B*15:02, HLA-B*15:11, HLA-B*57:01, HLA-B*58:01
- Alternative names & eponyms
- SJS; SJS/TEN spectrum
Etiology & mechanism
Drug-triggered cytotoxic T-cell reaction (granulysin, FasL) causing keratinocyte apoptosis.
Gene(s) involved (6)
Symptoms & signs (8)
In plain terms, someone with Stevens–Johnson syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
4 shared
Toxic epidermal necrolysis
fever, mucosal erosions, painful skin, skin detachment
2 shared
Behçet-like haploinsufficiency of A20 syndrome
fever, oral ulcers
2 shared
Familial cold autoinflammatory syndrome
conjunctivitis, fever
2 shared
Haploinsufficiency of A20 syndrome
fever, oral ulcers
2 shared
Kostmann syndrome
fever, oral ulcers
2 shared
Multisystem inflammatory syndrome in children
conjunctivitis, fever
2 shared
Sweet syndrome
conjunctivitis, fever
1 shared
Acquired immunodeficiency syndrome
fever
1 shared
Acute chest syndrome
fever
1 shared
Antisynthetase syndrome
fever
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