Stevens–Johnson syndrome

Also known as: SJS; SJS/TEN spectrum

Acute mucocutaneous reaction with detachment of under 10% body surface area.

Medical specialty: Dermatology
Subspecialty: Dermatology / Severe cutaneous adverse reactions
Sex & age distribution: Male: affected; Female: affected, slight female predominance; Children: yes, often drug or Mycoplasma related
Gene(s) involved: CYP2C9, HLA-A*31:01, HLA-B*15:02, HLA-B*15:11, HLA-B*57:01, HLA-B*58:01

Etiology & mechanism

Drug-triggered cytotoxic T-cell reaction (granulysin, FasL) causing keratinocyte apoptosis.

Gene(s) involved (6)

CYP2C9HLA-A*31:01HLA-B*15:02HLA-B*15:11HLA-B*57:01HLA-B*58:01

Symptoms & signs (8)

blistersconjunctivitisfevermucosal erosionsoral ulcerspainful skinskin detachmenttarget lesions

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.