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Dermatology · Dermatology / Severe cutaneous adverse reactions

DRESS syndrome

also: Drug reaction with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome
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Delayed drug reaction with rash, eosinophilia and organ involvement.

Specialty
Dermatology
Subspecialty
Dermatology / Severe cutaneous adverse reactions
Sex & age distribution
Male: affected; Female: affected, slight female predominance; Children: yes, less common
Gene(s) involved
HLA-A*31:01, HLA-A*32:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01
Alternative names & eponyms
Drug reaction with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome

Etiology & mechanism

T-cell mediated reaction with HHV-6/EBV reactivation.

Gene(s) involved (5)

HLA-A*31:01 HLA-A*32:01 HLA-B*15:02 HLA-B*57:01 HLA-B*58:01

Symptoms & signs (8)

In plain terms, someone with DRESS syndrome may experience the following — click any to explore related syndromes:

eosinophilia facial edema fever hepatitis lymphadenopathy morbilliform rash nephritis pneumonitis

Same gene(s)

Other syndromes that involve one of this syndrome's genes.

Overlapping symptoms

Other syndromes that share symptoms with this one.

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