Hematology · Hematology / Autoimmune cytopenias
Autoimmune lymphoproliferative syndrome
also: ALPS; Canale–Smith syndrome
Defective lymphocyte apoptosis with lymphoproliferation and autoimmune cytopenias.
- Specialty
- Hematology
- Subspecialty
- Hematology / Autoimmune cytopenias
- Sex & age distribution
- Male: affected; Female: affected; Children: yes, median onset about 2 years
- Gene(s) involved
- CASP10, CASP8, FAS, FASLG, KRAS, NRAS
- Alternative names & eponyms
- ALPS; Canale–Smith syndrome
Etiology & mechanism
FAS pathway defects.
Gene(s) involved (6)
Symptoms & signs (5)
In plain terms, someone with Autoimmune lymphoproliferative syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Evans syndrome
lymphadenopathy, splenomegaly
1 shared
Acquired immunodeficiency syndrome
lymphadenopathy
1 shared
APDS syndrome
lymphadenopathy
1 shared
Cartilage–hair hypoplasia syndrome
lymphoma risk
1 shared
Castleman syndrome
lymphadenopathy
1 shared
CTLA4 haploinsufficiency syndrome
autoimmune cytopenias
1 shared
DRESS syndrome
lymphadenopathy
1 shared
Felty syndrome
splenomegaly
1 shared
Gianotti–Crosti syndrome
lymphadenopathy
1 shared
Gray platelet syndrome
splenomegaly
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