Massive osteolysis due to lymphatic proliferation.
- Specialty
- Orthopedics
- Subspecialty
- Orthopedics / Bone tumors
- Sex & age distribution
- Male: affected; Female: affected, equal; Children: yes
- Gene(s) involved
- KRAS, PIK3CA
- Alternative names & eponyms
- Gorham–Stout syndrome
Etiology & mechanism
Lymphatic endothelial cell proliferation in bone.
Gene(s) involved (2)
Symptoms & signs (4)
In plain terms, someone with Gorham syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Gorham–Stout syndrome
chylothorax, pathologic fractures, progressive bone loss
1 shared
Blue rubber bleb nevus syndrome
pain
1 shared
Complex regional pain syndrome type I
pain
1 shared
Frey syndrome
pain
1 shared
Garcin syndrome
pain
1 shared
Guyon canal syndrome
pain
1 shared
Jaffe–Campanacci syndrome
pathologic fractures
1 shared
Maffucci syndrome
pathologic fractures
1 shared
Multiple hereditary exostoses syndrome
pain
1 shared
Ogilvie syndrome
pain
Shares genes with
1 shared
Autoimmune lymphoproliferative syndrome
KRAS
1 shared
Cardio-facio-cutaneous syndrome
KRAS
1 shared
Cardiofaciocutaneous syndrome
KRAS
1 shared
Cowden syndrome
PIK3CA
1 shared
Gorham–Stout syndrome
KRAS
1 shared
Klippel–Trénaunay syndrome
PIK3CA
1 shared
Klippel–Trénaunay syndrome with neurological involvement
PIK3CA
1 shared
Noonan syndrome
KRAS
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