Endocrinology · Endocrinology / Bone and mineral disorders
Gorham–Stout syndrome
also: Vanishing bone disease
Progressive osteolysis with lymphatic proliferation.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Bone and mineral disorders
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes
- Gene(s) involved
- KRAS, NRAS
- Alternative names & eponyms
- Vanishing bone disease
Etiology & mechanism
Lymphatic endothelial proliferation drives bone resorption.
Gene(s) involved (2)
Symptoms & signs (5)
In plain terms, someone with Gorham–Stout syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
3 shared
Gorham syndrome
chylothorax, pathologic fractures, progressive bone loss
1 shared
Camurati–Engelmann syndrome
bone pain
1 shared
Crush syndrome
limb swelling
1 shared
Fanconi syndrome
bone pain
1 shared
Jaffe–Campanacci syndrome
pathologic fractures
1 shared
Maffucci syndrome
pathologic fractures
1 shared
Mazabraud syndrome
bone pain
1 shared
McCune–Albright syndrome
bone pain
1 shared
Multiple endocrine neoplasia type 1
bone pain
1 shared
Schnitzler syndrome
bone pain
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