Endocrinology · Endocrinology / Pediatric endocrinology
McCune–Albright syndrome
also: Polyostotic fibrous dysplasia with endocrinopathy
Triad of fibrous dysplasia, café-au-lait macules and autonomous endocrine hyperfunction.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Pediatric endocrinology
- Sex & age distribution
- Male: affected, less often; Female: affected, more common; Children: yes, early childhood
- Gene(s) involved
- GNAS
- Alternative names & eponyms
- Polyostotic fibrous dysplasia with endocrinopathy
Etiology & mechanism
Somatic activating GNAS mosaic variant.
Gene(s) involved (1)
Symptoms & signs (10)
In plain terms, someone with McCune–Albright syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
2 shared
Mazabraud syndrome
bone pain, fractures
2 shared
Tumor-induced osteomalacia syndrome
bone pain, fractures
1 shared
Autoimmune polyglandular syndrome type 2
hyperthyroidism
1 shared
Camurati–Engelmann syndrome
bone pain
1 shared
Constitutional mismatch repair deficiency syndrome
café-au-lait macules
1 shared
Fanconi anemia
café-au-lait macules
1 shared
Fanconi syndrome
bone pain
1 shared
Gorham–Stout syndrome
bone pain
1 shared
Hajdu–Cheney syndrome
fractures
1 shared
Jaffe–Campanacci syndrome
café-au-lait macules
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