Clinical state of chronic glucocorticoid excess.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Adrenal disorders
- Sex & age distribution
- Male: affected; Female: affected, 3–5 times more common; Children: yes, rare
- Gene(s) involved
- ARMC5, CTNNB1, GNAS, MEN1, PDE11A, PDE8B, PRKACA, PRKAR1A, USP8
- Alternative names & eponyms
- Hypercortisolism
Etiology & mechanism
ACTH-secreting pituitary adenoma (Cushing disease), adrenal tumor, ectopic ACTH or exogenous steroid.
Gene(s) involved (9)
Symptoms & signs (13)
In plain terms, someone with Cushing syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
3 shared
Ectopic ACTH syndrome
diabetes, hypertension, proximal weakness
2 shared
Metabolic syndrome
central obesity, hypertension
2 shared
Werner syndrome
diabetes, osteoporosis
1 shared
Alport syndrome
hypertension
1 shared
Ask–Upmark kidney syndrome
hypertension
1 shared
Atypical hemolytic uremic syndrome
hypertension
1 shared
Bardet–Biedl syndrome
diabetes
1 shared
Congenital generalized lipodystrophy
hirsutism
1 shared
Conn syndrome
hypertension
1 shared
Donohue syndrome
hirsutism
Shares genes with
4 shared
Carney complex
PDE11A, PDE8B, PRKACA, PRKAR1A
1 shared
Carcinoid heart disease
MEN1
1 shared
Carcinoid syndrome
MEN1
1 shared
Conn syndrome
CTNNB1
1 shared
Glucagonoma syndrome
MEN1
1 shared
Hyperprolactinemia–galactorrhea syndrome
MEN1
1 shared
Insulinoma-associated neurological syndrome
MEN1
1 shared
Mazabraud syndrome
GNAS
1 shared
McCune–Albright syndrome
GNAS
1 shared
Multiple endocrine neoplasia type 1
MEN1
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