Cushing syndrome

Also known as: Hypercortisolism

Clinical state of chronic glucocorticoid excess.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Adrenal disorders
Sex & age distribution: Male: affected; Female: affected, 3–5 times more common; Children: yes, rare
Gene(s) involved: ARMC5, CTNNB1, GNAS, MEN1, PDE11A, PDE8B, PRKACA, PRKAR1A, USP8

Etiology & mechanism

ACTH-secreting pituitary adenoma (Cushing disease), adrenal tumor, ectopic ACTH or exogenous steroid.

Gene(s) involved (9)

ARMC5CTNNB1GNASMEN1PDE11APDE8BPRKACAPRKAR1AUSP8

Symptoms & signs (13)

buffalo humpcentral obesitydiabeteseasy bruisinghirsutismhypertensionmenstrual irregularitymood changemoon faceosteoporosispoor wound healingproximal weaknesspurple striae

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.