Severe insulin resistance with growth restriction and distinctive facies.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Diabetes
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, neonatal
- Gene(s) involved
- INSR
- Alternative names & eponyms
- Leprechaunism
Etiology & mechanism
Biallelic loss of insulin receptor function.
Gene(s) involved (1)
Symptoms & signs (7)
In plain terms, someone with Donohue syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Congenital generalized lipodystrophy
acanthosis nigricans, hirsutism
2 shared
Polycystic ovary syndrome
acanthosis nigricans, hirsutism
1 shared
Cushing syndrome
hirsutism
1 shared
Fanconi–Bickel syndrome
fasting hypoglycemia
1 shared
Hoyeraal–Hreidarsson syndrome
intrauterine growth restriction
1 shared
Meckel–Gruber syndrome
early death
1 shared
Rabson–Mendenhall syndrome
acanthosis nigricans
1 shared
Sengers syndrome
early death
1 shared
Silver–Russell syndrome
intrauterine growth restriction
1 shared
Transient neonatal diabetes syndrome
intrauterine growth restriction
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