Nephrology · Nephrology / Hereditary kidney disease
Alport syndrome
also: Hereditary nephritis with deafness
Hereditary basement membrane disorder with hematuria, progressive kidney failure, hearing loss and eye changes.
- Specialty
- Nephrology
- Subspecialty
- Nephrology / Hereditary kidney disease
- Sex & age distribution
- Male: affected, X-linked males severe with kidney failure by 20–40; Female: carriers with hematuria, some progress; Children: yes, hematuria in childhood
- Gene(s) involved
- COL4A3, COL4A4, COL4A5
- Alternative names & eponyms
- Hereditary nephritis with deafness
Etiology & mechanism
Defective type IV collagen alpha-3, alpha-4 and alpha-5 chains.
Gene(s) involved (3)
Symptoms & signs (7)
In plain terms, someone with Alport syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
3 shared
Nephritic syndrome
hematuria, hypertension, proteinuria
2 shared
Epstein syndrome
hematuria, proteinuria
2 shared
HELLP syndrome
hypertension, proteinuria
2 shared
Mirror syndrome
hypertension, proteinuria
2 shared
Nail–patella syndrome
hematuria, proteinuria
2 shared
Nutcracker syndrome
hematuria, proteinuria
2 shared
Pulmonary–renal syndrome
hematuria, proteinuria
2 shared
Renal coloboma syndrome
hypertension, proteinuria
1 shared
Action myoclonus–renal failure syndrome
proteinuria
1 shared
Alport syndrome with diffuse leiomyomatosis
hematuria
Shares genes with
Loading…
Loading…