Endocrinology · Endocrinology / Autoimmune endocrinology
Autoimmune polyglandular syndrome type 2
also: APS-2; Schmidt syndrome
Addison disease with autoimmune thyroid disease and/or type 1 diabetes.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Autoimmune endocrinology
- Sex & age distribution
- Male: affected; Female: affected, more common; Children: rare; adults aged 20–40
- Gene(s) involved
- CTLA4, HLA-DR3, HLA-DR4, MICA, PTPN22
- Alternative names & eponyms
- APS-2; Schmidt syndrome
Etiology & mechanism
HLA-associated polygenic autoimmunity.
Gene(s) involved (5)
Symptoms & signs (8)
In plain terms, someone with Autoimmune polyglandular syndrome type 2 may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
4 shared
Autoimmune polyglandular syndrome type 1
adrenal insufficiency, hypogonadism, pernicious anemia, vitiligo
2 shared
Sheehan syndrome
fatigue, hypothyroidism
1 shared
Atypical hemolytic uremic syndrome
fatigue
1 shared
Autoimmune polyendocrine syndrome type 1
adrenal insufficiency
1 shared
Bardet–Biedl syndrome
hypogonadism
1 shared
Barth syndrome
fatigue
1 shared
Benign hereditary chorea
hypothyroidism
1 shared
Börjeson–Forssman–Lehmann syndrome
hypogonadism
1 shared
Borjeson–Forssman–Lehmann syndrome
hypogonadism
1 shared
Camurati–Engelmann syndrome
fatigue
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