Autoimmune polyglandular syndrome type 2

Also known as: APS-2; Schmidt syndrome

Addison disease with autoimmune thyroid disease and/or type 1 diabetes.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Autoimmune endocrinology
Sex & age distribution: Male: affected; Female: affected, more common; Children: rare; adults aged 20–40
Gene(s) involved: CTLA4, HLA-DR3, HLA-DR4, MICA, PTPN22

Etiology & mechanism

HLA-associated polygenic autoimmunity.

Gene(s) involved (5)

CTLA4HLA-DR3HLA-DR4MICAPTPN22

Symptoms & signs (8)

adrenal insufficiencyfatiguehyperthyroidismhypogonadismhypothyroidismpernicious anemiatype 1 diabetesvitiligo

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