Endocrinology · Endocrinology / Autoimmune endocrinology
Autoimmune polyglandular syndrome type 1
also: APECED; APS-1; Whitaker syndrome
Triad of chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Autoimmune endocrinology
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, early childhood
- Gene(s) involved
- AIRE
- Alternative names & eponyms
- APECED; APS-1; Whitaker syndrome
Etiology & mechanism
AIRE loss impairs central immune tolerance.
Gene(s) involved (1)
Symptoms & signs (10)
In plain terms, someone with Autoimmune polyglandular syndrome type 1 may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
4 shared
Autoimmune polyglandular syndrome type 2
adrenal insufficiency, hypogonadism, pernicious anemia, vitiligo
3 shared
Autoimmune polyendocrine syndrome type 1
adrenal insufficiency, chronic mucocutaneous candidiasis, hypoparathyroidism
2 shared
Vogt–Koyanagi–Harada syndrome
alopecia, vitiligo
1 shared
Amelogenesis imperfecta with nephrocalcinosis syndrome
enamel hypoplasia
1 shared
Bardet–Biedl syndrome
hypogonadism
1 shared
Börjeson–Forssman–Lehmann syndrome
hypogonadism
1 shared
Borjeson–Forssman–Lehmann syndrome
hypogonadism
1 shared
CARASIL
alopecia
1 shared
Cronkhite–Canada syndrome
alopecia
1 shared
DRESS syndrome
hepatitis
Shares genes with
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