DRESS syndrome

Also known as: Drug reaction with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome

Delayed drug reaction with rash, eosinophilia and organ involvement.

Medical specialty: Dermatology
Subspecialty: Dermatology / Severe cutaneous adverse reactions
Sex & age distribution: Male: affected; Female: affected, slight female predominance; Children: yes, less common
Gene(s) involved: HLA-A*31:01, HLA-A*32:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01

Etiology & mechanism

T-cell mediated reaction with HHV-6/EBV reactivation.

Gene(s) involved (5)

HLA-A*31:01HLA-A*32:01HLA-B*15:02HLA-B*57:01HLA-B*58:01

Symptoms & signs (8)

eosinophiliafacial edemafeverhepatitislymphadenopathymorbilliform rashnephritispneumonitis

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.