Toxic epidermal necrolysis

Also known as: Lyell syndrome; TEN

Life-threatening skin detachment of over 30% body surface area.

Medical specialty: Dermatology
Subspecialty: Dermatology / Severe cutaneous adverse reactions
Sex & age distribution: Male: affected; Female: affected, slight female predominance; Children: yes, rare
Gene(s) involved: CYP2C9, HLA-A*31:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01

Etiology & mechanism

Drug-induced cytotoxic T-cell and NK-cell mediated keratinocyte death.

Gene(s) involved (5)

CYP2C9HLA-A*31:01HLA-B*15:02HLA-B*57:01HLA-B*58:01

Symptoms & signs (7)

dehydrationeye damagefevermucosal erosionspainful skinsepsisskin detachment

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.