Rheumatology · Rheumatology / Autoinflammatory disease
Cryopyrin-associated periodic syndrome
also: CAPS; familial cold autoinflammatory syndrome; Muckle–Wells syndrome; NOMID/CINCA
Spectrum of NLRP3 inflammasomopathies with urticaria-like rash, fever and sensorineural hearing loss.
- Specialty
- Rheumatology
- Subspecialty
- Rheumatology / Autoinflammatory disease
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, infancy
- Gene(s) involved
- NLRP3
- Alternative names & eponyms
- CAPS; familial cold autoinflammatory syndrome; Muckle–Wells syndrome; NOMID/CINCA
Etiology & mechanism
Gain-of-function NLRP3 variants cause IL-1 overproduction.
Gene(s) involved (1)
Symptoms & signs (8)
In plain terms, someone with Cryopyrin-associated periodic syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
2 shared
Dressler syndrome
arthralgia, fever
2 shared
Familial cold autoinflammatory syndrome
arthralgia, fever
2 shared
Muckle–Wells syndrome
amyloidosis, fever
2 shared
Schnitzler syndrome
arthralgia, fever
2 shared
Sweet syndrome
arthralgia, fever
1 shared
Acquired immunodeficiency syndrome
fever
1 shared
Acute chest syndrome
fever
1 shared
Alport syndrome
sensorineural hearing loss
1 shared
Antisynthetase syndrome
fever
1 shared
Behçet-like haploinsufficiency of A20 syndrome
fever
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