Rheumatology · Rheumatology / Autoimmune connective tissue disease
Sjögren syndrome
also: Gougerot–Sjögren syndrome; Sicca syndrome
Chronic autoimmune exocrinopathy with lymphocytic infiltration of lacrimal and salivary glands.
- Specialty
- Rheumatology
- Subspecialty
- Rheumatology / Autoimmune connective tissue disease
- Sex & age distribution
- Male: affected; Female: affected, 9:1 female predominance; Children: rare, juvenile Sjögren occurs
- Gene(s) involved
- BLK, CXCR5, HLA-DRB1*03, IL12A, IRF5, STAT4, TNFAIP3
- Alternative names & eponyms
- Gougerot–Sjögren syndrome; Sicca syndrome
Etiology & mechanism
Autoimmune epithelitis with anti-SSA/Ro and anti-SSB/La antibodies.
Gene(s) involved (7)
Symptoms & signs (11)
In plain terms, someone with Sjögren syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Sjögren syndrome kidney involvement
dry eyes, dry mouth, renal tubular acidosis
2 shared
Antisynthetase syndrome
interstitial lung disease, raynaud phenomenon
2 shared
Hypereosinophilic syndrome
fatigue, neuropathy
2 shared
Lambert–Eaton myasthenic syndrome
dry mouth, fatigue
2 shared
Mikulicz syndrome
dry eyes, dry mouth
2 shared
Post-Lyme disease syndrome
arthralgia, fatigue
1 shared
Abetalipoproteinemia
neuropathy
1 shared
Atypical hemolytic uremic syndrome
fatigue
1 shared
Autoimmune lymphoproliferative syndrome
lymphoma risk
1 shared
Autoimmune polyglandular syndrome type 2
fatigue
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