Sjögren syndrome

Also known as: Gougerot–Sjögren syndrome; Sicca syndrome

Chronic autoimmune exocrinopathy with lymphocytic infiltration of lacrimal and salivary glands.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Autoimmune connective tissue disease
Sex & age distribution: Male: affected; Female: affected, 9:1 female predominance; Children: rare, juvenile Sjögren occurs
Gene(s) involved: BLK, CXCR5, HLA-DRB1*03, IL12A, IRF5, STAT4, TNFAIP3

Etiology & mechanism

Autoimmune epithelitis with anti-SSA/Ro and anti-SSB/La antibodies.

Gene(s) involved (7)

BLKCXCR5HLA-DRB1*03IL12AIRF5STAT4TNFAIP3

Symptoms & signs (11)

arthralgiadental cariesdry eyesdry mouthfatigueinterstitial lung diseaselymphoma riskneuropathyparotid swellingraynaud phenomenonrenal tubular acidosis

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.