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Cardiology · Cardiology / Cardiac electrophysiology

Sick sinus syndrome

also: Sinus node dysfunction; tachycardia–bradycardia syndrome
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Impaired sinus node impulse formation or exit, causing bradycardia, pauses or alternating tachycardia and bradycardia.

Specialty
Cardiology
Subspecialty
Cardiology / Cardiac electrophysiology
Sex & age distribution
Male: affected; Female: affected equally to slightly higher; Children: yes, in congenital or post-surgical cases; mostly elderly
Gene(s) involved
ANK2, CACNA1D, GNB2, HCN4, KCNJ3, MYH6, SCN5A
Alternative names & eponyms
Sinus node dysfunction; tachycardia–bradycardia syndrome

Etiology & mechanism

Age-related fibrosis, ischemia, drugs or inherited ion channel defects reduce pacemaker function.

Gene(s) involved (7)

ANK2 CACNA1D GNB2 HCN4 KCNJ3 MYH6 SCN5A

Symptoms & signs (8)

In plain terms, someone with Sick sinus syndrome may experience the following — click any to explore related syndromes:

atrial fibrillation bradycardia dizziness exercise intolerance fatigue palpitations sinus pauses syncope

Same gene(s)

Other syndromes that involve one of this syndrome's genes.

Overlapping symptoms

Other syndromes that share symptoms with this one.

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