Underdevelopment of the left ventricle, mitral and aortic valves and ascending aorta.
- Specialty
- Cardiology
- Subspecialty
- Cardiology / Congenital heart disease
- Sex & age distribution
- Male: affected, slightly more common; Female: affected; Children: yes, neonates
- Gene(s) involved
- ETS1, GJA1, HAND1, MYH6, MYH7, NKX2-5, NOTCH1, SMAD6
- Alternative names & eponyms
- HLHS
Etiology & mechanism
Reduced fetal left-sided flow and genetic defects; ductal-dependent systemic circulation.
Gene(s) involved (8)
Symptoms & signs (7)
In plain terms, someone with Hypoplastic left heart syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
2 shared
Shone syndrome
poor feeding, tachypnea
1 shared
Acute respiratory distress syndrome
tachypnea
1 shared
Anomalous left coronary artery from pulmonary artery
poor feeding
1 shared
Blue baby syndrome
tachypnea
1 shared
Gordon syndrome
metabolic acidosis
1 shared
Heterotaxy syndrome
poor feeding
1 shared
Infant respiratory distress syndrome
tachypnea
1 shared
Lucey–Driscoll syndrome
poor feeding
1 shared
Meconium aspiration syndrome
tachypnea
1 shared
Neonatal abstinence syndrome
poor feeding
Shares genes with
2 shared
Shone syndrome
MYH6, NOTCH1
1 shared
Hallermann–Streiff syndrome
GJA1
1 shared
Heterotaxy syndrome
NKX2-5
1 shared
Jacobsen syndrome
ETS1
1 shared
Oculodentodigital dysplasia syndrome
GJA1
1 shared
Richter syndrome
NOTCH1
1 shared
Sick sinus syndrome
MYH6
1 shared
Wolff–Parkinson–White syndrome
NKX2-5
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