Cardiology · Cardiology / Endocrine hypertension
Gordon syndrome
also: familial hyperkalemic hypertension; Pseudohypoaldosteronism type II
Hypertension with hyperkalemia and metabolic acidosis from increased renal sodium chloride reabsorption.
- Specialty
- Cardiology
- Subspecialty
- Cardiology / Endocrine hypertension
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes
- Gene(s) involved
- CUL3, KLHL3, WNK1, WNK4
- Alternative names & eponyms
- familial hyperkalemic hypertension; Pseudohypoaldosteronism type II
Etiology & mechanism
Increased WNK–SPAK–NCC pathway activity.
Gene(s) involved (4)
Symptoms & signs (5)
In plain terms, someone with Gordon syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Conn syndrome
hypertension, muscle weakness
2 shared
Primary aldosteronism
hypertension, muscle weakness
2 shared
Turner syndrome cardiovascular disease
hypertension, short stature
1 shared
3M syndrome
short stature
1 shared
Aarskog–Scott syndrome
short stature
1 shared
Alport syndrome
hypertension
1 shared
Andersen–Tawil syndrome
short stature
1 shared
Ask–Upmark kidney syndrome
hypertension
1 shared
Atypical hemolytic uremic syndrome
hypertension
1 shared
Bartter syndrome
muscle weakness
Shares genes with
None.
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