Autonomous aldosterone production causing hypertension and hypokalemia.
- Specialty
- Cardiology
- Subspecialty
- Cardiology / Endocrine hypertension
- Sex & age distribution
- Male: affected; Female: affected, slightly more; Children: yes, familial forms
- Gene(s) involved
- ATP1A1, ATP2B3, CACNA1D, CACNA1H, CLCN2, CTNNB1, CYP11B1, CYP11B2, KCNJ5
- Alternative names & eponyms
- Conn syndrome
Etiology & mechanism
Adrenal adenoma or bilateral hyperplasia; familial forms from chimeric CYP11B1/CYP11B2.
Gene(s) involved (9)
Symptoms & signs (9)
In plain terms, someone with Primary aldosteronism may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
8 shared
Conn syndrome
headache, hypertension, hypokalemia, muscle weakness, palpitations, paresthesias, polydipsia, polyuria
5 shared
Bartter syndrome
cramps, hypokalemia, muscle weakness, polydipsia, polyuria
4 shared
Gitelman syndrome
cramps, hypokalemia, muscle weakness, palpitations
2 shared
Ask–Upmark kidney syndrome
headache, hypertension
2 shared
EAST syndrome
hypokalemia, muscle weakness
2 shared
Ectopic ACTH syndrome
hypertension, hypokalemia
2 shared
Ectopic Cushing syndrome
hypertension, hypokalemia
2 shared
Fanconi syndrome
polydipsia, polyuria
2 shared
Gordon syndrome
hypertension, muscle weakness
2 shared
HELLP syndrome
headache, hypertension
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