Primary aldosteronism

Also known as: Conn syndrome

Autonomous aldosterone production causing hypertension and hypokalemia.

Medical specialty: Cardiology
Subspecialty: Cardiology / Endocrine hypertension
Sex & age distribution: Male: affected; Female: affected, slightly more; Children: yes, familial forms
Gene(s) involved: ATP1A1, ATP2B3, CACNA1D, CACNA1H, CLCN2, CTNNB1, CYP11B1, CYP11B2, KCNJ5

Etiology & mechanism

Adrenal adenoma or bilateral hyperplasia; familial forms from chimeric CYP11B1/CYP11B2.

Gene(s) involved (9)

ATP1A1ATP2B3CACNA1DCACNA1HCLCN2CTNNB1CYP11B1CYP11B2KCNJ5

Symptoms & signs (9)

crampsheadachehypertensionhypokalemiamuscle weaknesspalpitationsparesthesiaspolydipsiapolyuria

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.