Gordon syndrome

Also known as: familial hyperkalemic hypertension; Pseudohypoaldosteronism type II

Hypertension with hyperkalemia and metabolic acidosis from increased renal sodium chloride reabsorption.

Medical specialty: Cardiology
Subspecialty: Cardiology / Endocrine hypertension
Sex & age distribution: Male: affected; Female: affected equally; Children: yes
Gene(s) involved: CUL3, KLHL3, WNK1, WNK4

Etiology & mechanism

Increased WNK–SPAK–NCC pathway activity.

Gene(s) involved (4)

CUL3KLHL3WNK1WNK4

Symptoms & signs (5)

hyperkalemiahypertensionmetabolic acidosismuscle weaknessshort stature

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.