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Cardiology · Cardiology / Cardiac electrophysiology

Brugada syndrome

also: Lai Tai; Sudden unexplained nocturnal death syndrome (SUNDS)
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ECG pattern of coved ST elevation in right precordial leads with risk of ventricular fibrillation in a structurally normal heart.

Specialty
Cardiology
Subspecialty
Cardiology / Cardiac electrophysiology
Sex & age distribution
Male: affected, about 8–10 times more common; Female: affected, less often; Children: rare, usually onset 30s–40s; fever-triggered events in children reported
Gene(s) involved
ABCC9, CACNA1C, CACNB2, FGF12, GPD1L, HCN4, KCND3, KCNE3, KCNE5, KCNJ8, PKP2, RANGRF, SCN1B, SCN2B, SCN3B, SCN5A, SEMA3A, SLMAP, TRPM4
Alternative names & eponyms
Lai Tai; Sudden unexplained nocturnal death syndrome (SUNDS)

Etiology & mechanism

Reduced sodium current or imbalance of transient outward current causes epicardial conduction heterogeneity in the right ventricular outflow tract.

Gene(s) involved (19)

ABCC9 CACNA1C CACNB2 FGF12 GPD1L HCN4 KCND3 KCNE3 KCNE5 KCNJ8 PKP2 RANGRF SCN1B SCN2B SCN3B SCN5A SEMA3A SLMAP TRPM4

Symptoms & signs (7)

In plain terms, someone with Brugada syndrome may experience the following — click any to explore related syndromes:

coved st elevation in v1–v3 fever-triggered events nocturnal agonal respiration palpitations sudden cardiac death syncope ventricular fibrillation

Same gene(s)

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Overlapping symptoms

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