Gastroenterology · Gastroenterology / Functional GI disorders
Irritable bowel syndrome
also: IBS; Spastic colon
Recurrent abdominal pain with altered bowel habit without structural cause.
- Specialty
- Gastroenterology
- Subspecialty
- Gastroenterology / Functional GI disorders
- Sex & age distribution
- Male: affected; Female: affected, 2:1 female predominance; Children: yes, adolescents
- Gene(s) involved
- SCN5A, SLC6A4, TNFSF15, TRPM8
- Alternative names & eponyms
- IBS; Spastic colon
Etiology & mechanism
Gut-brain axis dysregulation with visceral hypersensitivity and altered motility.
Gene(s) involved (4)
Symptoms & signs (7)
In plain terms, someone with Irritable bowel syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
3 shared
Blind loop syndrome
abdominal pain, bloating, diarrhea
2 shared
Carcinoid syndrome
abdominal pain, diarrhea
2 shared
Chilaiditi syndrome
abdominal pain, constipation
2 shared
Chronic intestinal pseudo-obstruction syndrome
abdominal pain, constipation
2 shared
Hyper-IgD syndrome
abdominal pain, diarrhea
2 shared
Juvenile polyposis syndrome
abdominal pain, diarrhea
2 shared
Microscopic colitis syndrome
abdominal pain, urgency
2 shared
Postcholecystectomy syndrome
bloating, diarrhea
1 shared
Acquired immunodeficiency syndrome
diarrhea
1 shared
Acute fatty liver of pregnancy syndrome
abdominal pain
Shares genes with
1 shared
Adams–Stokes syndrome
SCN5A
1 shared
Brugada syndrome
SCN5A
1 shared
Early repolarization syndrome
SCN5A
1 shared
Fibromyalgia syndrome
SLC6A4
1 shared
Long QT syndrome
SCN5A
1 shared
Sick sinus syndrome
SCN5A
1 shared
Sudden infant death syndrome
SCN5A
1 shared
Sudden infant death syndrome with cardiac cause
SCN5A
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