Irritable bowel syndrome

Also known as: IBS; Spastic colon

Recurrent abdominal pain with altered bowel habit without structural cause.

Medical specialty: Gastroenterology
Subspecialty: Gastroenterology / Functional GI disorders
Sex & age distribution: Male: affected; Female: affected, 2:1 female predominance; Children: yes, adolescents
Gene(s) involved: SCN5A, SLC6A4, TNFSF15, TRPM8

Etiology & mechanism

Gut-brain axis dysregulation with visceral hypersensitivity and altered motility.

Gene(s) involved (4)

SCN5ASLC6A4TNFSF15TRPM8

Symptoms & signs (7)

abdominal painbloatingconstipationdiarrheamucus in stoolrelief on defecationurgency

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.