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Hematology · Hematology / Hemolytic anemias

Donath–Landsteiner syndrome

also: Paroxysmal cold hemoglobinuria

Biphasic IgG hemolysin causing hemolysis after cold exposure.

Specialty
Hematology
Subspecialty
Hematology / Hemolytic anemias
Sex & age distribution
Male: affected; Female: affected; Children: yes, post-infectious
Gene(s) involved
None recorded
Alternative names & eponyms
Paroxysmal cold hemoglobinuria

Etiology & mechanism

Antibody-mediated complement lysis.

Gene(s) involved (0)

No gene recorded for this syndrome.

Symptoms & signs (4)

In plain terms, someone with Donath–Landsteiner syndrome may experience the following — click any to explore related syndromes:

Same gene(s)

Other syndromes that involve one of this syndrome's genes.

Overlapping symptoms

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