Donath–Landsteiner syndrome

Also known as: Paroxysmal cold hemoglobinuria

Biphasic IgG hemolysin causing hemolysis after cold exposure.

Medical specialty: Hematology
Subspecialty: Hematology / Hemolytic anemias
Sex & age distribution: Male: affected; Female: affected; Children: yes, post-infectious
Gene(s) involved: None recorded

Etiology & mechanism

Antibody-mediated complement lysis.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (4)

feverhemoglobinuriapallorsudden hemolysis after cold

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