Autoimmune hypercoagulable state with antiphospholipid antibodies, thrombosis and pregnancy loss.
- Specialty
- Hematology
- Subspecialty
- Hematology / Thrombosis and hemostasis
- Sex & age distribution
- Male: affected; Female: affected, 5 times more common; Children: yes, rare
- Gene(s) involved
- B2GP1, HLA-DR7, HLA-DRB1
- Alternative names & eponyms
- Hughes syndrome
Etiology & mechanism
Antibodies against beta-2 glycoprotein I and phospholipids activate endothelium and platelets.
Gene(s) involved (3)
Symptoms & signs (7)
In plain terms, someone with Antiphospholipid syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Upshaw–Schulman syndrome
stroke, thrombocytopenia
1 shared
Asherman syndrome
recurrent miscarriage
1 shared
Atypical hemolytic uremic syndrome
thrombocytopenia
1 shared
Behçet syndrome
venous thrombosis
1 shared
Bernard–Soulier syndrome
thrombocytopenia
1 shared
Deficiency of adenosine deaminase 2 syndrome
stroke
1 shared
Dengue shock syndrome
thrombocytopenia
1 shared
Eisenmenger syndrome
stroke
1 shared
HELLP syndrome
thrombocytopenia
1 shared
Hemolytic uremic syndrome
thrombocytopenia
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