Antiphospholipid syndrome

Also known as: Hughes syndrome

Autoimmune hypercoagulable state with antiphospholipid antibodies, thrombosis and pregnancy loss.

Medical specialty: Hematology
Subspecialty: Hematology / Thrombosis and hemostasis
Sex & age distribution: Male: affected; Female: affected, 5 times more common; Children: yes, rare
Gene(s) involved: B2GP1, HLA-DR7, HLA-DRB1

Etiology & mechanism

Antibodies against beta-2 glycoprotein I and phospholipids activate endothelium and platelets.

Gene(s) involved (3)

B2GP1HLA-DR7HLA-DRB1

Symptoms & signs (7)

arterial thrombosisheart valve diseaselivedo reticularisrecurrent miscarriagestrokethrombocytopeniavenous thrombosis

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