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Nephrology · Nephrology / Glomerular diseases

Nephrotic syndrome

also: Nephrosis
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Proteinuria over 3.5 g/day (or 40 mg/m2/h in children) with hypoalbuminemia, edema and hyperlipidemia.

Specialty
Nephrology
Subspecialty
Nephrology / Glomerular diseases
Sex & age distribution
Male: affected, more common in children; Female: affected, more common in adults with membranous or lupus forms; Children: yes, peak at 2–6 years
Gene(s) involved
ACTN4, ADCK4, APOL1, ARHGDIA, CD2AP, COQ2, COQ6, INF2, LAMB2, LMX1B, MYO1E, NPHS1, NPHS2, PLCE1, PTPRO, SMARCAL1, TRPC6, WT1
Alternative names & eponyms
Nephrosis

Etiology & mechanism

Podocyte injury or loss of glomerular filtration barrier from minimal change disease, FSGS, membranous nephropathy and others.

Gene(s) involved (18)

ACTN4 ADCK4 APOL1 ARHGDIA CD2AP COQ2 COQ6 INF2 LAMB2 LMX1B MYO1E NPHS1 NPHS2 PLCE1 PTPRO SMARCAL1 TRPC6 WT1

Symptoms & signs (10)

In plain terms, someone with Nephrotic syndrome may experience the following — click any to explore related syndromes:

ascites fatigue foamy urine hyperlipidemia hypoalbuminemia infections leg edema periorbital edema thromboembolism weight gain

Same gene(s)

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Overlapping symptoms

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