Neurology · Neurology / Movement disorders; Autonomic neurology
Multiple system atrophy
also: olivopontocerebellar atrophy (historical); Shy–Drager syndrome (historical)
Sporadic adult-onset alpha-synucleinopathy with autonomic failure and parkinsonism or cerebellar ataxia.
- Specialty
- Neurology
- Subspecialty
- Neurology / Movement disorders; Autonomic neurology
- Sex & age distribution
- Male: slightly more common; Female: affected; Children: no
- Gene(s) involved
- COQ2, GBA1, SNCA
- Alternative names & eponyms
- olivopontocerebellar atrophy (historical); Shy–Drager syndrome (historical)
- Note
- Overlaps #661, #662, #709 and #911
Etiology & mechanism
Oligodendroglial cytoplasmic inclusions of alpha-synuclein with striatonigral and olivopontocerebellar degeneration.
Gene(s) involved (3)
Symptoms & signs (6)
In plain terms, someone with Multiple system atrophy may experience the following — click any to explore related syndromes:
Same gene(s)
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Overlapping symptoms
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