Diabetes insipidus, diabetes mellitus, optic atrophy and deafness.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Diabetes
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, diabetes by age 6
- Gene(s) involved
- CISD2, WFS1
- Alternative names & eponyms
- DIDMOAD syndrome
Etiology & mechanism
Endoplasmic reticulum stress and beta-cell loss.
Gene(s) involved (2)
Symptoms & signs (7)
In plain terms, someone with Wolfram syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Brown–Vialetto–Van Laere syndrome
ataxia, optic atrophy, sensorineural deafness
3 shared
Thiamine-responsive megaloblastic anemia syndrome
diabetes mellitus, optic atrophy, sensorineural deafness
2 shared
EAST syndrome
ataxia, sensorineural deafness
2 shared
Hartnup syndrome
ataxia, psychiatric symptoms
2 shared
Perrault syndrome
ataxia, sensorineural deafness
1 shared
Abetalipoproteinemia
ataxia
1 shared
Acquired cerebellar syndrome
ataxia
1 shared
Action myoclonus–renal failure syndrome
ataxia
1 shared
Angelman syndrome
ataxia
1 shared
Barakat syndrome
sensorineural deafness
Shares genes with
None.
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