Wolfram syndrome

Also known as: DIDMOAD syndrome

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Diabetes
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, diabetes by age 6
Gene(s) involved: CISD2, WFS1

Etiology & mechanism

Endoplasmic reticulum stress and beta-cell loss.

Gene(s) involved (2)

CISD2WFS1

Symptoms & signs (7)

ataxiadiabetes insipidusdiabetes mellitusneurogenic bladderoptic atrophypsychiatric symptomssensorineural deafness

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.