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Endocrinology · Endocrinology / Pediatric endocrinology

WAGR syndrome

also: Wilms tumor, aniridia, genitourinary anomalies, range of developmental delays

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Contiguous gene deletion syndrome at 11p13.

Specialty: Endocrinology
Subspecialty: Endocrinology / Pediatric endocrinology
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, birth
Gene(s) involved: BDNF, PAX6, WT1
Alternative names & eponyms: Wilms tumor, aniridia, genitourinary anomalies, range of developmental delays

Etiology & mechanism

Deletion of WT1 and PAX6, with BDNF deletion causing obesity.

Gene(s) involved (3)

BDNF PAX6 WT1

Symptoms & signs (6)

In plain terms, someone with WAGR syndrome may experience the following — click any to explore related syndromes:

aniridia childhood-onset obesity genitourinary anomalies hyperphagia intellectual disability wilms tumor

Same gene(s)

Other syndromes that involve one of this syndrome's genes.

Overlapping symptoms

Other syndromes that share symptoms with this one.

Drag nodes, scroll to zoom, click a node to open that syndrome.

Shares symptoms with

Aniridia-Wilms tumor-genitourinary anomalies-retardation syndrome

aniridia, genitourinary anomalies, intellectual disability, wilms tumor

Prader–Willi syndrome

hyperphagia, intellectual disability

Allan–Herndon–Dudley syndrome

intellectual disability

intellectual disability

Börjeson–Forssman–Lehmann syndrome

intellectual disability

Borjeson–Forssman–Lehmann syndrome

intellectual disability

Cardiofaciocutaneous syndrome

intellectual disability

Coffin–Lowry syndrome

intellectual disability

Coffin–Siris syndrome

intellectual disability

intellectual disability

Shares genes with

Aniridia-Wilms tumor-genitourinary anomalies-retardation syndrome

BDNF, PAX6, WT1

Central alveolar hypoventilation syndrome

Denys–Drash syndrome

Frasier syndrome

Nephrotic syndrome

Peters plus syndrome

Septo-optic dysplasia

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