Neurology · Neurology / Movement disorders; Neurodegenerative disease
Progressive supranuclear palsy
also: PSP; Steele–Richardson–Olszewski syndrome
Atypical parkinsonism with vertical supranuclear gaze palsy and early falls.
- Specialty
- Neurology
- Subspecialty
- Neurology / Movement disorders; Neurodegenerative disease
- Sex & age distribution
- Male: slightly more common; Female: affected; Children: no
- Gene(s) involved
- EIF2AK3, LRRK2, MAPT, MOBP, STX6
- Alternative names & eponyms
- PSP; Steele–Richardson–Olszewski syndrome
Etiology & mechanism
4-repeat tau pathology in brainstem, basal ganglia and cortex.
Gene(s) involved (5)
Symptoms & signs (6)
In plain terms, someone with Progressive supranuclear palsy may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Foix–Chavany–Marie syndrome
dysarthria, dysphagia
2 shared
Osmotic demyelination syndrome
dysarthria, dysphagia
2 shared
Pseudobulbar palsy
dysarthria, dysphagia
1 shared
Acquired cerebellar syndrome
dysarthria
1 shared
Alport syndrome with diffuse leiomyomatosis
dysphagia
1 shared
Avellis syndrome
dysphagia
1 shared
Brainstem stroke syndrome
dysarthria
1 shared
Collet–Sicard syndrome
dysphagia
1 shared
Eagle syndrome
dysphagia
1 shared
Facial-onset sensory and motor neuronopathy
dysphagia
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