Progressive supranuclear palsy

Also known as: PSP; Steele–Richardson–Olszewski syndrome

Atypical parkinsonism with vertical supranuclear gaze palsy and early falls.

Medical specialty: Neurology
Subspecialty: Neurology / Movement disorders; Neurodegenerative disease
Sex & age distribution: Male: slightly more common; Female: affected; Children: no
Gene(s) involved: EIF2AK3, LRRK2, MAPT, MOBP, STX6

Etiology & mechanism

4-repeat tau pathology in brainstem, basal ganglia and cortex.

Gene(s) involved (5)

EIF2AK3LRRK2MAPTMOBPSTX6

Symptoms & signs (6)

axial rigiditydysarthriadysphagiaearly postural instability with fallsfrontal cognitive impairmentvertical gaze palsy

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