Dermatology · Dermatology / Genodermatoses
Papillon–Lefèvre syndrome
also: Palmoplantar keratoderma with periodontitis
Palmoplantar keratoderma with severe early periodontitis.
- Specialty
- Dermatology
- Subspecialty
- Dermatology / Genodermatoses
- Sex & age distribution
- Male: affected; Female: affected, equal; Children: yes, onset 1–5 years
- Gene(s) involved
- CTSC
- Alternative names & eponyms
- Palmoplantar keratoderma with periodontitis
Etiology & mechanism
Cathepsin C deficiency impairing neutrophil serine protease activation.
Gene(s) involved (1)
Symptoms & signs (5)
In plain terms, someone with Papillon–Lefèvre syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
2 shared
Leukocyte adhesion deficiency syndrome
periodontitis, recurrent infections
1 shared
Bare lymphocyte syndrome
recurrent infections
1 shared
Barth syndrome
recurrent infections
1 shared
Chediak–Higashi syndrome
recurrent infections
1 shared
Chédiak–Higashi syndrome
recurrent infections
1 shared
DiGeorge syndrome
recurrent infections
1 shared
Felty syndrome
recurrent infections
1 shared
Good syndrome
recurrent infections
1 shared
Haim–Munk syndrome
periodontitis
1 shared
Heterotaxy syndrome
recurrent infections
Shares genes with
Loading…
Loading…