Neurology · Neurology / Mitochondrial disease
MELAS syndrome
also: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes
Maternally inherited stroke-like syndrome.
- Specialty
- Neurology
- Subspecialty
- Neurology / Mitochondrial disease
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, typical onset 2–40 years, usually before 40
- Gene(s) involved
- MT-CO3, MT-ND1, MT-ND5, MT-TH, MT-TK, MT-TL1, MT-TQ, MT-TS1, POLG
- Alternative names & eponyms
- Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes
Etiology & mechanism
MT-TL1 mutation.
Gene(s) involved (9)
Symptoms & signs (8)
In plain terms, someone with MELAS syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
2 shared
Barakat syndrome
seizures, sensorineural deafness
2 shared
EAST syndrome
seizures, sensorineural deafness
2 shared
Hashimoto encephalopathy syndrome
seizures, stroke-like episodes
2 shared
LEOPARD syndrome
sensorineural deafness, short stature
2 shared
Nicolaides–Baraitser syndrome
seizures, short stature
2 shared
Ramsay Hunt syndrome type 1
cognitive decline, seizures
2 shared
SHORT syndrome
diabetes, short stature
2 shared
Sturge–Weber syndrome
seizures, stroke-like episodes
2 shared
Werner syndrome
diabetes, short stature
1 shared
3M syndrome
short stature
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