Gastroenterology · Gastroenterology / Polyposis syndromes
Lynch syndrome
also: Hereditary nonpolyposis colorectal cancer
Hereditary mismatch repair deficiency with colorectal, endometrial and other cancers.
- Specialty
- Gastroenterology
- Subspecialty
- Gastroenterology / Polyposis syndromes
- Sex & age distribution
- Male: affected, higher colorectal cancer risk; Female: affected, with endometrial cancer risk; Children: rare, cancers from early adulthood
- Gene(s) involved
- EPCAM, MLH1, MSH2, MSH6, PMS2
- Alternative names & eponyms
- Hereditary nonpolyposis colorectal cancer
Etiology & mechanism
Germline mismatch repair gene mutation causing microsatellite instability.
Gene(s) involved (5)
Symptoms & signs (6)
In plain terms, someone with Lynch syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
Drag nodes, scroll to zoom, click a node to open that syndrome.
Shares symptoms with
1 shared
Constitutional mismatch repair deficiency syndrome
colorectal cancer
1 shared
Cowden syndrome
endometrial cancer
1 shared
Gardner syndrome
colorectal cancer
1 shared
Hereditary breast and ovarian cancer syndrome
ovarian cancer
1 shared
Muir–Torre syndrome
colorectal cancer
1 shared
Serrated polyposis syndrome
colorectal cancer
1 shared
Turcot syndrome
colorectal cancer
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