Autosomal dominant hypertension with hypokalemia and low renin and aldosterone.
- Specialty
- Cardiology
- Subspecialty
- Cardiology / Endocrine hypertension
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes, early onset
- Gene(s) involved
- SCNN1A, SCNN1B, SCNN1G
- Alternative names & eponyms
- Pseudoaldosteronism
Etiology & mechanism
Gain of function of the epithelial sodium channel increases sodium reabsorption.
Gene(s) involved (3)
Symptoms & signs (6)
In plain terms, someone with Liddle syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Bartter syndrome
hypokalemia, metabolic alkalosis, muscle weakness
3 shared
EAST syndrome
hypokalemia, metabolic alkalosis, muscle weakness
2 shared
Conn syndrome
hypokalemia, muscle weakness
2 shared
Gitelman syndrome
hypokalemia, muscle weakness
2 shared
Primary aldosteronism
hypokalemia, muscle weakness
2 shared
Verner–Morrison syndrome
hypokalemia, muscle weakness
1 shared
Burnett syndrome
metabolic alkalosis
1 shared
Camurati–Engelmann syndrome
muscle weakness
1 shared
Congenital chloride diarrhea syndrome
metabolic alkalosis
1 shared
Ectopic ACTH syndrome
hypokalemia
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