Neurology · Neurology / Epilepsy; Pediatric neurology
Lennox–Gastaut syndrome
also: Childhood epileptic encephalopathy with diffuse slow spike-wave
Childhood-onset developmental and epileptic encephalopathy defined by multiple seizure types, slow spike-wave on EEG and cognitive impairment.
- Specialty
- Neurology
- Subspecialty
- Neurology / Epilepsy; Pediatric neurology
- Sex & age distribution
- Male: slightly more common; Female: affected; Children: yes, onset typically 1–8 years
- Gene(s) involved
- ALG13, CHD2, DNM1, GABRB3, GRIN2A, GRIN2B, KCNA2, SCN8A, STXBP1, SYNGAP1
- Alternative names & eponyms
- Childhood epileptic encephalopathy with diffuse slow spike-wave
Etiology & mechanism
Heterogeneous: structural injury or malformation, prior infantile spasms, genetic causes, or unknown.
Gene(s) involved (10)
Symptoms & signs (8)
In plain terms, someone with Lennox–Gastaut syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
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Shares symptoms with
2 shared
Lujan–Fryns syndrome
behavioral problems, intellectual disability
2 shared
Prader–Willi syndrome
behavioral problems, intellectual disability
1 shared
Allan–Herndon–Dudley syndrome
intellectual disability
1 shared
Aniridia-Wilms tumor-genitourinary anomalies-retardation syndrome
intellectual disability
1 shared
Apert syndrome
intellectual disability
1 shared
Börjeson–Forssman–Lehmann syndrome
intellectual disability
1 shared
Borjeson–Forssman–Lehmann syndrome
intellectual disability
1 shared
Cardiofaciocutaneous syndrome
intellectual disability
1 shared
Coffin–Lowry syndrome
intellectual disability
1 shared
Coffin–Siris syndrome
intellectual disability
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