Hematology · Hematology / Bone marrow failure
Job syndrome
also: Buckley syndrome; Hyper-IgE syndrome
Primary immunodeficiency with eczema, recurrent skin and lung infections and high IgE.
- Specialty
- Hematology
- Subspecialty
- Hematology / Bone marrow failure
- Sex & age distribution
- Male: affected; Female: affected equally; Children: yes
- Gene(s) involved
- DOCK8, PGM3, SPINK5, STAT3, ZNF341
- Alternative names & eponyms
- Buckley syndrome; Hyper-IgE syndrome
Etiology & mechanism
STAT3 dominant negative variants.
Gene(s) involved (5)
Symptoms & signs (7)
In plain terms, someone with Job syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Hyperimmunoglobulin E syndrome
cold abscesses, eczema, scoliosis
1 shared
Börjeson–Forssman–Lehmann syndrome
coarse facies
1 shared
Borjeson–Forssman–Lehmann syndrome
coarse facies
1 shared
Cantú syndrome
coarse facies
1 shared
Coffin–Lowry syndrome
coarse facies
1 shared
Coffin–Siris syndrome
coarse facies
1 shared
Costello syndrome
coarse facies
1 shared
Hajdu–Cheney syndrome
coarse facies
1 shared
Hunter syndrome
coarse facies
1 shared
Hurler syndrome
coarse facies
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