Recurrent staphylococcal infections, eczema and high IgE.
- Specialty
- Pediatrics
- Subspecialty
- Pediatrics / Pediatric immunology
- Sex & age distribution
- Male: affected; Female: affected, equal; Children: yes, infancy
- Gene(s) involved
- DOCK8, PGM3, SPINK5, STAT3
- Alternative names & eponyms
- Job syndrome
Etiology & mechanism
STAT3 dominant-negative mutations.
Gene(s) involved (4)
Symptoms & signs (6)
In plain terms, someone with Hyperimmunoglobulin E syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Job syndrome
cold abscesses, eczema, scoliosis
1 shared
Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome
eczema
1 shared
IPEX syndrome
eczema
1 shared
Klippel–Feil syndrome
scoliosis
1 shared
Marfan syndrome
scoliosis
1 shared
Netherton syndrome
elevated ige
1 shared
Proteus syndrome
scoliosis
1 shared
Rett syndrome
scoliosis
1 shared
Shprintzen–Goldberg syndrome
scoliosis
1 shared
Sotos syndrome
scoliosis
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