Neurology · Neurology / Movement disorders; Neurogenetics
Hereditary spastic paraplegia type 21
also: Mast syndrome; SPG21
Recessive HSP with dementia, thin corpus callosum.
- Specialty
- Neurology
- Subspecialty
- Neurology / Movement disorders; Neurogenetics
- Sex & age distribution
- Male: affected; Female: affected equally; Children: onset in adolescence to adult
- Gene(s) involved
- SPG21
- Alternative names & eponyms
- Mast syndrome; SPG21
Etiology & mechanism
Maspardin (ACP33) mutations.
Gene(s) involved (1)
Symptoms & signs (3)
In plain terms, someone with Hereditary spastic paraplegia type 21 may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Action myoclonus–renal failure syndrome
ataxia, dementia
2 shared
Triple H syndrome
ataxia, spastic paraparesis
1 shared
Abetalipoproteinemia
ataxia
1 shared
Acquired cerebellar syndrome
ataxia
1 shared
Angelman syndrome
ataxia
1 shared
Brown–Vialetto–Van Laere syndrome
ataxia
1 shared
Cerebral folate deficiency syndrome
ataxia
1 shared
Dandy–Walker malformation
ataxia
1 shared
Dravet syndrome
ataxia
1 shared
EAST syndrome
ataxia
Shares genes with
None.
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