Hereditary spastic paraplegia type 21

Also known as: Mast syndrome; SPG21

Recessive HSP with dementia, thin corpus callosum.

Medical specialty: Neurology
Subspecialty: Neurology / Movement disorders; Neurogenetics
Sex & age distribution: Male: affected; Female: affected equally; Children: onset in adolescence to adult
Gene(s) involved: SPG21

Etiology & mechanism

Maspardin (ACP33) mutations.

Gene(s) involved (1)

SPG21

Symptoms & signs (3)

ataxiadementiaspastic paraparesis

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