Endocrinology · Endocrinology / Metabolic disorders
Familial partial lipodystrophy
also: Dunnigan syndrome; Kobberling–Dunnigan syndrome
Loss of limb and gluteal fat with central fat accumulation and insulin resistance.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Metabolic disorders
- Sex & age distribution
- Male: affected; Female: affected, more severe metabolic disease; Children: yes, onset at puberty
- Gene(s) involved
- AKT2, CIDEC, LIPE, LMNA, PLIN1, PPARG
- Alternative names & eponyms
- Dunnigan syndrome; Kobberling–Dunnigan syndrome
Etiology & mechanism
LMNA and other adipocyte gene variants.
Gene(s) involved (6)
Symptoms & signs (8)
In plain terms, someone with Familial partial lipodystrophy may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Alström syndrome
fatty liver, hypertriglyceridemia
2 shared
Congenital generalized lipodystrophy
fatty liver, hypertriglyceridemia
2 shared
SHORT syndrome
diabetes, insulin resistance
1 shared
Bardet–Biedl syndrome
diabetes
1 shared
Chanarin–Dorfman syndrome
fatty liver
1 shared
Cushing syndrome
diabetes
1 shared
Ectopic ACTH syndrome
diabetes
1 shared
Glucagonoma syndrome
diabetes
1 shared
Hemophagocytic lymphohistiocytosis
hypertriglyceridemia
1 shared
Lemmel syndrome
pancreatitis
Shares genes with
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